Study On 432

Cognitive Neuropsychiatry. 2014 Jan 24
Amelioration of psychiatric symptoms through exposure to music individually adapted to brain rhythm disorders -- a randomized clinical trial on the basis of fundamental research.
by Muller W., Haffelder G, Schlotmann A, Schaefers AT, Teuchert-Noodt G.
Abstract
Introduction:
This pilot study examined, whether long-term exposure of psychiatric patients to music that was individually adapted to brain rhythm disorders associated with psychosis could act to ameliorate psychiatric symptoms. Methods A total of 50 patients with various psychiatric diagnoses were randomized in a 1:1 ratio to listen to CDs containing either music adapted to brain rhythm anomalies associated with psychoticism -- measured via a specific spectral analysis -- or standard classical music.
Participants were instructed to listen to the CDs over the next 18 months. Psychiatric symptoms in both groups were assessed at baseline and at 4, 8 and 18 months, using the Brief Symptom Inventory (BSI).
Results:
At 18 months, patients in the experimental group showed significantly decreased BSI scores compared to control patients. Intriguingly, this effect was not only seen for symptoms of psychosis and paranoia but also for anxiety, phobic anxiety and somatisation.
Conclusions Exposure to the adapted music*(see below) was effective in ameliorating psychotic, anxiety and phobic symptoms. Based on the theories of neuro-plasticity and brain rhythms, it can be hypothesized that this intervention may be enhancing brain-rhythm synchronization and plasticity in prefrontal-hippocampal circuits that are implicated in both psychosis/paranoia and anxiety/phobic anxiety.
*"adapted music" = (excerpt from report) "This "Mozart effect" can be intensified by playing the music composition slightly decelerated (as practiced in the days of Mozart). Furthermore, the instruments are tuned to the old French pitch of 432 Hz which corresponds to the harmonic ratio of natural body rhythms including ..."

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